A Role for Neutrophil Recruitment? Blood-Brain Barrier Integrity through TNF: Central Nervous System Infiltration and Meningeal Mast Cells Affect Early T Cell
نویسندگان
چکیده
منابع مشابه
P164: The Role of Mast Cells in the Pathogenesis of Anxiety Disorders
Mast cells are a heterogeneous population of granulocytic cells in the immune system. Mast cell granules contain numerous mediators, including neurotransmitters, cytokines, chemokines and lipid-derived factors. In addition to their well-known role in immune inflammation, the presence of mast cells in the meninges and perivascular space in the central nervous system points to their role in brain...
متن کاملP167: Key Role of Inflammation in Central Nervous System Damage and Disease; TNFα, IL-1
Inflammation is portion of the body's immune response and it is basically a host protective response to tissue ischemia, injury, autoimmune responses or infectious agents. Although the information presented so far points to a detrimental role for inflammation in central nervous system (CNS) disease, it may also be useful. CNS demonstrates characteristic of inflammation, and in response to damag...
متن کاملNK cells promote neutrophil recruitment in the brain during sepsis-induced neuroinflammation
Sepsis could affect the central nervous system and thus induces neuroinflammation, which subsequently leads to brain damage or dysfunction. However, the mechanisms of generation of neuroinflammation during sepsis remain poorly understood. By administration of lipopolysaccharides (LPS) in mice to mimic sepsis, we found that shortly after opening the blood-brain barrier, conventional CD11b(+)CD27...
متن کاملP27: KCNK2 and Adhesion Molecules in an in-Vitro Blood Brain Barrier Model
Two-pore domain potassium channels, like KCNK2, are known to play an important role in inflammatory diseases such as multiple sclerosis (MS). Upregulation of cellular adhesion molecules in mouse brain microvascular endothelial cells (MBMECs) of Kcnk2-/- mice resulted in elevated leukocyte trafficking into the central nervous system under inflammatory conditions. The current project aims to gain...
متن کاملMast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice.
Both mast cells and IL-17 can contribute to host defense and pathology in part by orchestrating neutrophil recruitment, but the possible role of mast cells in IL-17-induced inflammation remains to be defined. We found that mast cells and IL-17, but neither IFN-gamma nor FcRgamma signaling, contributed significantly to the antigen (Ag)-dependent airway neutrophilia elicited in ovalbumin-specific...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010